Inhibitor potency varies widely among tumor-relevant human isocitrate dehydrogenase 1 mutants
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چکیده
منابع مشابه
Arabidopsis NAD-dependent isocitrate dehydrogenase mutants
NAD-dependent isocitrate dehydrogenase (IDH) is a TCA cycle enzyme that produces 2oxoglutarate, an organic acid required by the glutamine synthetase/glutamate synthase cycle to assimilate ammonium. Three Arabidopsis IDH mutants have been characterized, corresponding to an insertion into a different IDH gene (At5g03290, idhv; At4g35260, idhi; At2g17130, idhii). Analysis of IDH mRNA and protein s...
متن کاملIdentification of a New Selective Chemical Inhibitor of Mutant Isocitrate Dehydrogenase-1
BACKGROUND Recent genome-wide sequencing studies have identified unexpected genetic alterations in cancer. In particular, missense mutations in isocitrate dehydrogenase-1 (IDH1) at arginine 132, mostly substituted into histidine (IDH1-R132H) were observed to frequently occur in glioma patients. METHODS We have purified recombinant IDH1 and IDH1-R132H proteins and monitored their catalytic act...
متن کاملThe Period Length of Fibroblast Circadian Gene Expression Varies Widely among Human Individuals
Mammalian circadian behavior is governed by a central clock in the suprachiasmatic nucleus of the brain hypothalamus, and its intrinsic period length is believed to affect the phase of daily activities. Measurement of this period length, normally accomplished by prolonged subject observation, is difficult and costly in humans. Because a circadian clock similar to that of the suprachiasmatic nuc...
متن کاملRole of isocitrate dehydrogenase 1/2 (IDH 1/2) gene mutations in human tumors.
In recent years, frequent isocitrate dehydrogenase 1/2 (IDH1/IDH2) gene mutations were found in a variety of tumors, which specifically alter arginine residues of catalytic active site in IDH1/IDH2 and confer new enzymatic function of directly catalyzing alpha-ketoglutarate (α-KG) to R-2-hydroxyglutarate (2-HG). 2-HG could competitively inhibit α-KG-dependent enzymes and might therefore contrib...
متن کاملArteriovenous malformation within an isocitrate dehydrogenase 1 mutated anaplastic oligodendroglioma
BACKGROUND The co-occurrence of intracranial arteriovenous malformations (AVMs) and cerebral neoplasms is exceedingly rare but may harbor implications pertaining to the molecular medicine of brain cancer pathogenesis. CASE DESCRIPTION Here, we present a case of de novo AVM within an isocitrate dehydrogenase 1 mutated anaplastic oligodendroglioma (WHO Grade III) and review the potential contri...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 2018
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bcj20180424